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The principal cytochrome P450 isoenzyme concerned seems to be CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Close to 85% of the oral dose appears in the urine within 24 hours of administration, most given that the glucuronide conjugate, with smaller quantities of other conjugates and unchanged drug.The concomitant usage of opioids with other op